Foot-and-Mouth Disease (FMD)
Foot-and-mouth disease (FMD) is a highly contagious, notifiable viral disease of cows and buffaloes that causes fever and blisters in the mouth and feet. RT-PCR on blister samples and antibody ELISAs help confirm it.
Signs owners may notice
- High fever and dullness
- Heavy, stringy drooling and lip smacking
- Blisters or raw sores on the tongue, gums and lips
- Blisters between the hooves, and lameness
- Sores on the teats
- Not eating, and a sudden drop in milk yield
- Sudden death in young calves
Signs alone cannot name a disease. If your animal looks unwell, see a veterinarian promptly.
How lab tests help
RT-PCR on blister fluid, the skin of fresh blisters or a mouth swab can confirm the virus, and serotyping shows which type is present. The NSP antibody ELISA can show past or current infection, and the structural-protein ELISA is used to check how a herd responded to vaccine. A registered veterinarian reads the results with the herd's signs and history.
What is foot-and-mouth disease?
Foot-and-mouth disease (FMD) is a highly contagious viral disease of animals with split hooves, including cows, buffaloes, sheep, goats and pigs. In many villages it is called khurpaka-munhpaka. The virus spreads very fast through direct contact, saliva, milk, dung and breath, and on feed, vehicles, equipment, clothes and shoes.
FMD is a notifiable disease, which means cases must be reported. If you suspect it, tell your veterinarian or the animal husbandry department.
Most adult animals survive, but milk yield and fertility can stay low for a long time, and pregnant animals may abort. Young calves can die suddenly, because the virus can damage the heart.
Signs to watch for
Common signs include:
- High fever and dullness
- Heavy, stringy drooling and lip smacking
- Blisters or raw sores on the tongue, gums and lips
- Blisters between the hooves, and lameness
- Sores on the teats
- Not eating, and a sudden drop in milk
Which lab tests help
The FMD Virus RT-PCR looks for the virus's genetic material in blister fluid, the skin covering fresh blisters, or mouth swabs. Samples are taken by a veterinarian. The FMD Virus Serotyping (O, A & Asia 1) shows which type of FMD virus is present; this may be done through a reference laboratory, and the lab confirms this when you book.
Antibody tests, which look for the proteins the body makes against the virus, answer different questions. The FMD NSP (3ABC) Antibody ELISA looks for antibodies that point to past or current infection rather than vaccination. The FMD Structural-Protein Antibody ELISA (Vaccine Response) measures antibodies that rise after vaccination, so it is used to see how a herd responded to vaccine. It does not tell you exactly how protected an animal is. The FMD (Foot-and-Mouth Disease) Test - RT-PCR / ELISA is the lab's general FMD test; the lab confirms the method when you book.
A registered veterinarian interprets every result together with the herd's signs, vaccination and history. Testing helps confirm the disease, but it cannot by itself stop an outbreak.
When to see your vet
Call your vet at once if animals have fever, drooling, mouth blisters or lameness. Tell your veterinarian or the animal husbandry department, and follow their guidance. Ask your vet about vaccination.
Testing in Bhopal
Pashupatinath Vet Lab is in Shahpura, Bhopal, and provides free sample collection anywhere in Bhopal. For suspected FMD, call the lab on +91 88175 01118 before sending anything, so it can confirm how samples taken by your vet should be packed and sent. From other districts, samples come through your local vet, by courier or by bus parcel. The Herd Screening Pack includes an FMD test with brucellosis, tick fever and worm tests. The lab confirms the method, sample needs and reporting time when you book.
Lab tests that may help
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FMD (Foot-and-Mouth Disease) Test - RT-PCR / ELISA
Vesicular fluid / epithelium / swab (PCR); serum (ELISA)
Price on request
Packages
Herd Screening Pack
Screen a dairy herd for brucellosis, FMD, tick fever and worms.
- Brucellosis Test
- FMD Test
- Tick Fever Panel (Cattle & Buffalo)
- Fecal Worm Egg Count
- + 2 more tests
Call to confirm
Common questions
How is FMD confirmed in cows and buffaloes?
Is FMD a notifiable disease?
What is the difference between the NSP and vaccine-response FMD tests?
Can FMD spread through people and vehicles?
This guide is general information for animal owners. It does not diagnose or treat any animal. A registered veterinarian should examine the animal and read all test results together with its signs and history.
Read more
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Cattle Viral RT-PCR Panel: FMD, LSD, BVD, Bluetongue and IBR
A cattle viral RT-PCR panel tests for five viruses in one booking: FMD, lumpy skin disease, BVD, bluetongue and IBR. It helps when a sick cow or buffalo has signs that fit more than one virus.
18 Oct 2026
Foot-and-Mouth Disease: Sample and Notification Guide for Farmers
Foot-and-mouth disease (FMD) is a highly contagious notifiable disease that causes fever, blisters and a fall in milk. A vet takes the samples for RT-PCR and antibody tests, and owners should tell their veterinarian or the animal husbandry department.
18 Oct 2026